Striatal subregional 6-[18F]fluoro-L-dopa uptake in early Parkinson's disease : A two-year follow-up study
Identifieur interne : 003626 ( Main/Exploration ); précédent : 003625; suivant : 003627Striatal subregional 6-[18F]fluoro-L-dopa uptake in early Parkinson's disease : A two-year follow-up study
Auteurs : Anna Brück [Finlande] ; Sargo Aalto [Finlande] ; Elina Nurmi [Finlande] ; Tero Vahlberg [Finlande] ; Jorgen Bergman [Finlande] ; Juha O. Rinne [Finlande]Source :
- Movement disorders [ 0885-3185 ] ; 2006.
Descripteurs français
- Pascal (Inist)
English descriptors
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Abstract
Thirty-one drug-naive patients with Parkinson's disease (PD) underwent 6-[18F]fluoro-L-dopa (F-dopa) positron emission tomography (PET) scan at the time of the diagnosis (baseline) and 2 years later in order to investigate F-dopa uptake in striatal and extrastriatal regions during the first years of early PD. Twenty-four healthy controls underwent one F-dopa PET scan. The regional differences in the striatal and extrastriatal regions were analyzed with statistical parametric mapping and automated region of interest analyses. Our study shows that the F-dopa uptake in unmedicated early PD is most severely decreased in the dorsal part of caudal putamen but significant decrease can be seen throughout the striatum compared with controls. During the first years of PD, there is a progressive regional decline in striatal F-dopa uptake, the dorsal part of caudal putamen being still the most severely affected region. The absolute decline is equal between the striatal subregions. This suggests that the decline of dopamine function starts from the dorsocaudal putamen, but once started, the rate of progression is equal between the subregions of the striatum. In contrast to the striatal decline, the increased cortical F-dopa uptake prevails at least during the first years of PD.
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Rinne</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Turku PET Center, University of Turku</s1><s2>Turku</s2><s3>FIN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Finlande</country><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region></placeName><orgName type="university">Université de Turku</orgName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Emission tomography</term><term>Fluorodopa(18F)</term><term>Follow up study</term><term>Levodopa</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Positron emission tomography</term><term>Uptake</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term><term>Parkinson maladie</term><term>Lévodopa</term><term>Captation</term><term>Etude longitudinale</term><term>Tomoscintigraphie</term><term>Tomographie émission positon</term><term>Fluorodopa(18F)</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Thirty-one drug-naive patients with Parkinson's disease (PD) underwent 6-[<sup>18</sup>F]fluoro-L-dopa (F-dopa) positron emission tomography (PET) scan at the time of the diagnosis (baseline) and 2 years later in order to investigate F-dopa uptake in striatal and extrastriatal regions during the first years of early PD. Twenty-four healthy controls underwent one F-dopa PET scan. The regional differences in the striatal and extrastriatal regions were analyzed with statistical parametric mapping and automated region of interest analyses. Our study shows that the F-dopa uptake in unmedicated early PD is most severely decreased in the dorsal part of caudal putamen but significant decrease can be seen throughout the striatum compared with controls. During the first years of PD, there is a progressive regional decline in striatal F-dopa uptake, the dorsal part of caudal putamen being still the most severely affected region. The absolute decline is equal between the striatal subregions. This suggests that the decline of dopamine function starts from the dorsocaudal putamen, but once started, the rate of progression is equal between the subregions of the striatum. In contrast to the striatal decline, the increased cortical F-dopa uptake prevails at least during the first years of PD.</div></front></TEI><affiliations><list><country><li>Finlande</li></country><region><li>Finlande occidentale</li></region><settlement><li>Turku</li></settlement><orgName><li>Université de Turku</li></orgName></list><tree><country name="Finlande"><region name="Finlande occidentale"><name sortKey="Bruck, Anna" sort="Bruck, Anna" uniqKey="Bruck A" first="Anna" last="Brück">Anna Brück</name></region><name sortKey="Aalto, Sargo" sort="Aalto, Sargo" uniqKey="Aalto S" first="Sargo" last="Aalto">Sargo Aalto</name><name sortKey="Bergman, Jorgen" sort="Bergman, Jorgen" uniqKey="Bergman J" first="Jorgen" last="Bergman">Jorgen Bergman</name><name sortKey="Bruck, Anna" sort="Bruck, Anna" uniqKey="Bruck A" first="Anna" last="Brück">Anna Brück</name><name sortKey="Nurmi, Elina" sort="Nurmi, Elina" uniqKey="Nurmi E" first="Elina" last="Nurmi">Elina Nurmi</name><name sortKey="Rinne, Juha O" sort="Rinne, Juha O" uniqKey="Rinne J" first="Juha O." last="Rinne">Juha O. Rinne</name><name sortKey="Vahlberg, Tero" sort="Vahlberg, Tero" uniqKey="Vahlberg T" first="Tero" last="Vahlberg">Tero Vahlberg</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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